Ventilatory and Orthostatic Challenges Reveal Biomarkers for Neurocognition in Children and Young Adults With Congenital Central Hypoventilation Syndrome.

Susan M Slattery,Frank A Zelko,Eric L Vu,Emma C Dunne,Casey M Rand,Allison Bradley,Amy Zhou,Michael S Carroll,Ilya Khaytin,Kenneth M Brady,Tracey M Stewart,Debra E Weese-Mayer

Chest（2023）

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摘要

In children and young adults with CCHS, SpO and HR-or change in HR-at rest and as a response to hypoxia and orthostasis are related to cognitive outcomes in domains of known risk, particularly fluid reasoning. These findings can guide additional research on the usefulness of these as biomarkers in understanding the impact of daily physical stressors on neurodevelopment in this high-risk group.

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关键词

ANSD,CCHS,autonomic nervous system dysfunction,cognitive outcomes,congenital central hypoventilation syndrome,head-up tilt,neurocognition,orthostatic challenges,ventilatory challenges

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