The Effect of TNF-alpha rs1800629 Polymorphism on White Matter Structures and Memory Function in Patients With Schizophrenia: A Pilot Study.

Naok Kang,Wonsuk Shin,Sra Jung,Minji Bang,Sang-Hyuk Lee

Psychiatry investigation（2022）

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摘要

Our findings suggest that the A-allele, which is associated with higher levels of TNF-α expression, correlates with lower connectivity of the fronto-temporal white matter compared to that in GG homozygotes. Impaired fronto-temporal connectivity may be associated with genetic vulnerability to schizophrenia, leading to verbal and visual memory deficits in patients with schizophrenia.

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关键词

Diffusion tensor imaging,Neurocognition,Neuroinflammation,Schizophrenia,TNF-alpha,White matter

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