Retina-arrestin specific CD8+ T cells are not implicated in HLA-A29-positive birdshot chorioretinitis

W J Venema,S Hiddingh,G M C Janssen, J Ossewaarde, N Dam van Loon,J H de Boer,P A van Veelen,J J W Kuiper

Clinical Immunology（2023）

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摘要

•Peptides from retinal arrestin (SAG) are natural ligands of HLA-A29 in cell lines from birdshot chorioretinitis patients.•ERAP aminopeptidases can generate SAG-derived peptides by trimming precursor peptides.•CD8+ T cells reactive to SAG peptides in complex with HLA-A29 are not detected in blood or eye biopsies of patients.

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关键词

SAG,HLA-A29,BCR

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