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A correlative biomarker study and integrative prognostic model in chemotherapy-naïve metastatic castration-resistant prostate cancer treated with enzalutamide.

María P Fernandez-Perez,Enrique Perez-Navarro,Teresa Alonso-Gordoa,Vicenza Conteduca,Albert Font,Sergio Vázquez-Estévez,Aránzazu González-Del-Alba,Daniel Wetterskog,Emmanuel S Antonarakis,Begona Mellado,Ovidio Fernandez-Calvo,María J Méndez-Vidal,Miguel A Climent,Ignacio Duran,Enrique Gallardo,Angel Rodriguez Sanchez,Carmen Santander,Maria I Sáez,Javier Puente,Julian Tudela,Alberto Martínez,Maria J López-Andreo, José Padilla,Rebeca Lozano,David Hervas,Jun Luo,Ugo de Giorgi,Daniel Castellano,Gerhardt Attard,Enrique Grande,Enrique Gonzalez-Billalabeitia

The Prostate（2023）

Cited 2|Views48
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Abstract
TMPRSS2-ERG detection did not correlate with differential activity of enzalutamide in first-line mCRPC. However, we observed that CTCs and plasma AR gain were the most relevant biomarkers.
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Key words
AR gain,AR-V7,CTCs,TMPRSS2-ERG,enzalutamide,prostate cancer
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