Protein Profiling in Presymptomatic Individuals Separates Myeloperoxidase-Antineutrophil Cytoplasmic Antibody and Proteinase 3-Antineutrophil Cytoplasmic Antibody Vasculitides.

Mikael Brink,Ewa Berglin,Aladdin J Mohammad,Anders Lundquist,Inger Gjertsson,Andrey Alexeyenko,Kristina Lejon,Solbritt Rantapää-Dahlqvist

Arthritis & rheumatology (Hoboken, N.J.)（2022）

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摘要

To our knowledge, this is the first study to identify protein markers preceding symptom onset in AAV patients. These findings set the stage for further research into the underlying cellular and molecular mechanisms in the pathogenesis of AAV and the diversification of patients into PR3-ANCA+ and MPO-ANCA+ subphenotypes.

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