Heightened Procoagulation after Post-Operative Thromboprophylaxis Completion in Patients with Metastatic Bone Disease from Primary Colorectal Cancer.

Lisa Yamaura,Daniel Young,Leslie Skeith,Michael J Monument,Craig N Jenne,Antoine Dufour,Prism Schneider,Ejaife O Agbani

Journal of clinical medicine（2022）

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摘要

Our data elucidates the cell biology of a prothrombo-inflammatory state caused by disease and vascular injury, and recalcitrant to thromboprophylaxis. New mechanistic insights into hypercoagulability in CRC/MBD patients may identify novel drug targets for effective thromboprophylaxis type and duration after orthopaedic surgery.

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关键词

colorectal cancer,metastatic bone disease,orthopaedic surgery,platelet procoagulant membrane dynamics (PMD),venous thromboembolism

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