Discordant immune response among treatment experienced patients infected with HIV-1: Crosstalk between MiRNAs expression and CD4+ T cells count

Shima Poorghobadi,Mina Agharezaei,Maryam Ghanbari,Golnaz Bahramali,Ladan Abbasian,Mansour Sajadipour,Kazem Baesi

International Immunopharmacology（2023）

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摘要

•Discordant immune response is a failure to satisfactorily increase CD4 counts on ART despite successful viral load control.•miR30b, miR155, miR181a and miR190b are involved in the proliferation and development of CD4 T cells.•MiRNA expression may be one of the reasons for the lack of increase in CD4 T cells in immunological discordance patients.

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Discordant Immune Response,HIV,miRNAs expression

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