Fusobacterium nucleatum induces colon anastomosis leak by activating epithelial cells to express MMP9.

Shang Shi,Yang Liu,Zhiyue Wang,Xiangren Jin,Wei Yan,Xiao Guo,Baiqiang Lin,Haoran Wang,Bowen Li,Jianjun Zheng,Yunwei Wei

Frontiers in microbiology（2022）

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摘要

This work demonstrates that attaches and then stimulates the expression of epithelial cells MMP9 by the E-cadherin/β-catenin signaling pathway. These effects contribute to collagen break down in the intestinal tissue, finally leading to AL.

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关键词

Fusobacterium nucleatum,adhesion ability,anastomotic leak,colorectal cancer,matrix metalloproteinase 9

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