Evaluation of transmission-blocking potential of Pv22 using clinical Plasmodium vivax infections and transgenic Plasmodium berghei

Jie Bai,Fei Liu,Fan Yang,Yan Zhao,Xitong Jia,Sataporn Thongpoon, Wanlapa Roobsoog,Jetsumon Sattabongkot,Li Zheng, Zeshi Cui,Wenqi Zheng,Liwang Cui,Yaming Cao

Vaccine（2023）

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摘要

•We generated transgenic P. berghei parasites expressing Pv22.•We used the transgenic parasites to evaluate Pv22′s transmission-blocking potential.•Clinical P. vivax isolates were used in membrane feeding.•Antibodies against rPv22 significantly reduced the oocyst density in mosquitoes.•Feeding assay results disfavor Pv22 as a promising TBV candidate.

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关键词

Plasmodium vivax,Antibodies,Rodent malaria parasite,Transgenic parasite,Transmission-blocking vaccine

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