Effects of food and race on the pharmacokinetics of lazertinib in healthy subjects and patients with EGFR mutation-positive advanced non-small cell lung cancer
Lung Cancer(2023)
摘要
•The systemic exposure of lazertinib was not significantly altered by food.•Lazertinib can be administered without regard to food, enhancing the patient's adherence to treatment.•Non-Asian and Asian patients showed similar systemic exposure both after single and multiple doses of lazertinib.•No separate dose adjustment of lazertinib for race is required.
更多查看译文
关键词
ADR,AE,ANOVA,AUC,AUCinf,AUCss,AUCt,BCRP,CI,CL/F,Clast,Cmax,Cmax,CNS,CYP,DN,ECG,ECOG PS,EDTA,EGFR,NSCLC,PK,QD,t1/2,T790M,TKI,Tmax,Vd/F,λz
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要