Urinary cell mRNA profiling of kidney allograft recipients: Development of a portable protocol for noninvasive diagnosis of T cell mediated rejection and BK virus nephropathy

Thalia Salinas,Carol Li,Catherine Snopkowski,Gabriel Stryjniak,Divya Shankaranarayanan,Shady Albakry,Ruchuang Ding,Vijay K Sharma,Steven P Salvatore,Surya V Seshan,Darshana M Dadhania,Thangamani Muthukumar,Manikkam Suthanthiran

Journal of Immunological Methods（2023）

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摘要

Urine processed using the WCHP predicted TCMR and BKVN in kidney allograft recipients. WCHP represents not only a significant advance toward the portability of urinary cell mRNA profiling but also improved patient management by minimizing their visits for urine collection.

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关键词

RT-qPCR,Transplantation,BKV,T cell mediated rejection (TCMR),mRNA,Urine

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