Exposure-Response Analyses of Tremelimumab Monotherapy or in Combination with Durvalumab in Patients with Unresectable Hepatocellular Carcinoma.

Xuyang Song,Robin Kate Kelley,Anis A Khan,Nathan Standifer,Diansong Zhou,KyoungSoo Lim,Rajesh Krishna,Lu Liu,Kun Wang,Patricia McCoon,Alejandra Negro,Philip He,Megan Gibbs,John F Kurland,Ghassan K Abou-Alfa

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Our findings support novel insights into tremelimumab pharmacokinetics and exposure-response relationships in HCC and support the clinical utility of the STRIDE regimen in patients with uHCC.

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关键词

tremelimumab monotherapy,hepatocellular carcinoma,unresectable hepatocellular carcinoma,durvalumab,exposure-response

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