Inhomogeneous Magnetization Transfer (ihMT) imaging in the acute cuprizone mouse model of demyelination/remyelination

Andreea Hertanu,Lucas Soustelle,Julie Buron,Julie Le Priellec,Myriam Cayre,Arnaud Le Troter,Valentin H Prevost,Jean-Philippe Ranjeva,Gopal Varma,David C Alsop,Pascale Durbec,Olivier M Girard,Guillaume Duhamel

NeuroImage（2023）

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摘要

•IhMT is a sensitive biomarker of de-/remyelination in the acute cuprizone mouse model.•IhMT targeted toward long T1D components correlates with myelin histology.•IhMT targeted toward short T1D components correlates less with myelin histology.•Spatial-temporal extent of cuprizone-induced myelin alterations is best described by ihMT T1D-filters.•MPF correlates with myelin histology, but is less sensitive than ihMT to characterize the spatial extent of demyelination in the acute cuprizone model.

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关键词

Myelin MR imaging,ihmt T1D-filters,Demyelination,Remyelination,cuprizone mouse model,histology

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