Potent predictive CpG signature for temozolomide response in non-glioma-CpG island methylator phenotype glioblastomas with methylated MGMT promoter.
Epigenomics(2022)
摘要
We aimed to identify potent CpG signatures predicting temozolomide (TMZ) response in glioblastomas (GBMs) that do not have the glioma-CpG island methylator phenotype (G-CIMP) but have a methylated promoter of (me). Different datasets of non-G-CIMP me GBMs with molecular and clinical data were analyzed. A panel of 77 TMZ efficacy-related CpGs and a seven-CpG risk signature were identified and validated for distinguishing differential outcomes to radiotherapy plus TMZ versus radiotherapy alone in non-G-CIMP me GBMs. An integrated classification scheme was also proposed for refining a -based TMZ-guiding approach in all G-CIMP-GBMs. The CpG signatures may serve as promising predictive biomarker candidates for guiding optimal TMZ usage in non-G-CIMP me GBMs.
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关键词
DNA methylation,glioblastoma,methylated MGMT,predictive biomarker,temozolomide
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