Myelin heterogeneity for assessing normal appearing white matter myelin damage in multiple sclerosis.

Poljanka Johnson,Irene M Vavasour,Biljana Jonoska Stojkova,Shawna Abel,Lisa Eunyoung Lee,Cornelia Laule,Roger Tam,David K B Li,Nathalie Ackermans,Alice J Schabas,Jillian Chan,Helen Cross,Ana-Luiza Sayao,Virginia Devonshire,Robert Carruthers,Anthony Traboulsee,Shannon H Kolind

Journal of neuroimaging : official journal of the American Society of Neuroimaging（2023）

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摘要

Mean MWF, SD, and MHI provide complementary information when assessing regional and global NAWM abnormalities in MS and associations with clinical outcome measures. Examining all three metrics (mean MWF, SD, and MHI) enables a more detailed interpretation of results, depending on whether regions of interest include areas that are more heterogeneous, earlier in the demyelination process, or uniformly injured.

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关键词

MRI,demyelination,disability,multiple sclerosis,myelin water imaging,neuroimaging

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