Efficacy of an adjuvant non-face-to-face multimodal lifestyle modification program for patients with treatment-resistant major depression: A randomized controlled trial

•Therapies for treatment-resistant depression need to be improved.•Lifestyle modification might be effective against treatment-resistant depression.•Insufficient patient recruitment probably prevented confirmation in this study.•Our program improved life quality and decreased use of antidepressants.•The COVID-19 pandemic made it difficult to perform more thorough evaluations.