The long-lasting effects of early life adversities are sex dependent: The signature of miR-34a

Sebastian Luca D'Addario,Diana Municchi,Camilla Mancini,Donald Ielpo,Lucy Babicola,Matteo Di Segni,Luisa Lo Iacono,Fabio Ferlazzo,Carlo Cifani,Diego Andolina,Rossella Ventura

Journal of Affective Disorders（2023）

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摘要

•Early life adversity induces a depressive-like state in female mice.•Early life adversity affects miR-34a expression only in female mice.•Early life adversity modulates miR-34a response to adult acute stress exposure in female mice.•MiR-34a expression in DRN correlates with plasmatic miR-34a levels.

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关键词

Early adversities,microRNA-34a,Sex differences,Passive coping behavior,Animal model of depression-like state

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