The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles.

Mari Lahelma,Sami Qadri,Noora Ahlholm,Kimmo Porthan,Maija Ruuth,Anne Juuti,Matej Orešič,Tuulia Hyötyläinen,Katariina Öörni,Hannele Yki-Järvinen

Atherosclerosis（2022）

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摘要

Lipid composition of LDL reflects that of the human liver in obese patients. Changes in hepatic sphingolipid metabolism may contribute to interindividual variation of LDL lipid composition and susceptibility to aggregation.

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关键词

Atherosclerosis,Cardiovascular disease,Ceramides,Cholesterol,Lipidomics,Phosphatidylcholines,Triglycerides

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