Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer.
Pancreatology（2023）
摘要
Loss of PI3K-C2γ prevents mTOR inactivation and triggers tumour vulnerability to RAD001 (mTOR inhibitor) and BPTES/CB-839 (glutaminase inhibitors). Therefore, these results might open the way to personalised treatments in PDAC with PI3K-C2γ loss.
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关键词
AMINO ACIDS,CELL BIOLOGY,LIPID METABOLISM,PANCREATIC CANCER,SIGNAL TRANSDUCTION
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