A sensitive LC-MS method for the determination of Sinomenine derivative SWX and its application to pharmacokinetic research in rats

Binbin Ge,Xuejian Wang,Wan Li,Sha Li,Yanmei Du,Tengfei Ji,Guanhua Du,Chunyan Fang,Jinhua Wang

Journal of Chromatography B（2022）

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摘要

•First reported of determination of Sinomenine derivative SWX in rats plasma by HPLC-MS/MS.•First reported of pharmacokinetic study of Sinomenine derivative SWX after intragastric and intravenous administration in rats.•The method was used to analyze samples from pharmacokinetics studies in Sprague–Dawley rats.

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关键词

Sinomenine,SWX,Pharmacokinetics,Tissue distribution,LC-MS,Bioavailability

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