Synaptic loss in frontotemporal dementia revealed by [ 11 C]UCB-J PET.

Maura Malpetti,P Simon Jones,Thomas E Cope,Negin Holland,Michelle Naessens,Matthew A Rouse,Timothy Rittman,George Savulich,David J Whiteside,Duncan Street,Tim D Fryer,Young T Hong,Selena Milicevic Sephton,Franklin I Aigbirhio,John T O'Brien,James B Rowe

Annals of neurology（2022）

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摘要

In accordance with preclinical models, and human post mortem evidence, there is widespread frontotemporal loss of synapses in symptomatic bvFTD, in proportion to severity. [ C]UCB-J PET could support translational studies and experimental medicine strategies for new disease-modifying treatments for neurodegeneration. This article is protected by copyright. All rights reserved.

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