Treatment with COLchicine in hospitalized patients affected by COVID-19: The COLVID-19 trial

Carlo Perricone,Mirko Scarsi,Antonio Brucato, Paola Pisano,Erika Pigatto,Cecilia Becattini,Antonella Cingolani, Francesco Tiso,Roberto Prota,Lina Rachele Tomasoni,Maurizio Cutolo,Marika Tardella,Davide Rozza, Carlo Zerbino,Massimo Andreoni,Venerino Poletti,Elena Bartoloni,Roberto Gerli

European Journal of Internal Medicine（2022）

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摘要

•Colchicine is not superior to standard of care in reducing the risk of mortality, clinical worsening or mechanical ventilation in hospitalized patients with COVID-19 pneumonia.•Colchicine should be administered with caution in the advanced phases of the disease.•Older patients with comorbidities (pre-existent heart, lung, upper-gastrointestinal, lower-gastrointestinal diseases, and cancer) are characterized by worse outcome.

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关键词

COVID-19,SARS-CoV-2,Coronavirus,Colchicine,Anti-IL-1,Inflammation

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