Biomarkers and treatment trials in animal models to prevent posttraumatic epilepsy

Investigating biomarkers and potential therapies in animal models is essential to determine which target mechanisms could prevent posttraumatic epilepsy (PTE). In theory, an ideal candidate biomarker should be easily measurable (noninvasive) and specific for PTE (distinct from traumatic brain injury (TBI) and epilepsy biomarkers) while an ideal therapeutic agent would be efficacious at preventing the development of seizures and secondary injuries associated with brain injury. In this chapter, we will discuss biomarkers and therapeutic interventions that reduce seizure susceptibility examined in animal models of PTE.