T Cells Chemotaxis Migration Studies with a Multi-Channel Microfluidic Device
MICROMACHINES(2022)
摘要
Immune surveillance is dependent on lymphocyte migration and targeted recruitment. This can involve different modes of cell motility ranging from random walk to highly directional environment-guided migration driven by chemotaxis. This study protocol describes a flow-based microfluidic device to perform quantitative multiplex cell migration assays with the potential to investigate in real time the migratory response of T cells at the population or single-cell level. The device also allows for subsequent in situ fixation and direct fluorescence analysis of the cells in the microchannel.
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关键词
chemotaxis, T cells, migration, microfluidic device, multi-channel
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