Duck Enteritis Virus Protein Kinase US3 Inhibits DNA Sensing Signaling by Phosphorylating Interferon Regulatory Factor 7

Rui Liu,Li Gao,Fuchun Yang,Xiaohan Li,Changjun Liu,Xiaole Qi,Hongyu Cui,Yanping Zhang,Suyan Wang,Xiaomei Wang,Yulong Gao,Kai Li

Microbiology Spectrum（2022）

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摘要

Duck enteritis virus (DEV) is a duck alphaherpesvirus that causes an acute and contagious disease with high mortality, resulting in substantial economic losses in the commercial waterfowl industry. The evasion of DNA-sensing pathway-mediated antiviral innate immunity is essential for the persistent infection and replication for many DNA viruses.

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关键词

duck enteritis virus,DNA sensing,interferon regulatory factor 7,US3

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