Investigation of Iron Release from the N- and C- Lobes of Human Serum Transferrin by Quantum Chemical Calculations

Basak Fındık, Umut Cilesiz,Semiha Kevser Bali,Canan Atilgan,Viktorya Aviyente,Burcu Dedeoglu

Organic & Biomolecular Chemistry（2022）

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摘要

Human serum transferrin binds ferric ions with high affinity and delivers them into cells via receptor-mediated endocytosis upon a decrease in pH in the endosome. Protonation events and conformational changes...

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