Altered Patterns of Brain Glucose Metabolism Involve More Extensive and Discrete Cortical Areas in Treatment-resistant Schizophrenia Patients Compared to Responder Patients and Controls: Results From a Head-to-Head 2-[18F]-FDG-PET Study.

Felice Iasevoli,Luigi D'Ambrosio,Mariateresa Ciccarelli,Annarita Barone,Valeria Gaudieri,Sirio Cocozza,Giuseppe Pontillo,Arturo Brunetti,Alberto Cuocolo,Andrea de Bartolomeis,Sabina Pappatà

Schizophrenia bulletin（2023）

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摘要

These data indicate that, in TRS patients, altered metabolism involved discrete brain regions not found affected in nTRS, possibly indicating a more severe disrupted functional brain network associated with disorganization symptoms.

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关键词

antipsychotics,clozapine,dopamine,glutamate,prefrontal cortex,superior frontal gyrus

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