492 Bi-layered skin construct with gene modified keratinocytes reduces UVR DNA damage

Ultraviolet radiation (UVR) is among major contributors to skin cancer in humans. Production of melanin serves as a main defense mechanisms against UVR damage. This pigment, which gives color to hair, skin and eyes, protects the underlying tissue from UVR damage. However, in some patient populations, this protection mechanism is not effective, leaving patients highly susceptible to cancer. Similarly, mycosporine like amino acids (MAAs), which are commonly expressed in marine algae, have been shown to serve a protective role in UVR-induced DNA damage.