Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand

Lei Ma,Junyuan Tang,Guihui Cai,Fangyuan Chen,Qingmei Liu,Zhi Zhou,Silin Zhang,Xiawen Liu,Ning Hou,Wei Yi

Bioorganic Chemistry（2022）

引用 0|浏览3

暂无评分

摘要

•Dic was revealed to be a potent SPPARγM by SB-VHTS and assays in vitro.•Dic exhibited weaker promotion of adipose differentiation than TZD drugs.•Dic showed anti-diabetic effects without body and organ weight gains in db/db mice.•Dic regulated the insulin-relative genes by inhibiting pPPARγ Ser273.•Dic performed a unique binding mode with PPARγ LBD.

查看译文

关键词

Anti-diabetic effects,Dicoumarol,Insulin sensitivity,SB-VHTS,SPPARγM,T2DM

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要