Tumour infiltrating B cells discriminate checkpoint blockade-induced responses

Sara Valpione,Luca G. Campana,John Weightman,Zena Salih,Elena Galvani,Piyushkumar A. Mundra,Francesco De Rosa,Avinash Gupta,Patricio Serra-Bellver,Paul Lorigan, Theodora Germetaki,Marek Dynowski, Stephen Kitcatt,Sudhakar Sahoo, Dave Lee,Nathalie Dhomen,Graham Lord,Richard Marais

European Journal of Cancer（2022）

引用 1|浏览15

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摘要

•Pre-treatment tumour infiltrating B cell clonotype abundance discriminate response to ICB (99 characters).•B cells likely contribute to anti-tumour immunity by antigen presentation (74 characters).•On-treatment B cell gene expression in the tumour-infiltrate identifies responders to ICB (93 characters).

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关键词

Melanoma,Immunotherapy,Lymphocytes,B cell clonotypes

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