Diffusion along perivascular spaces provides evidence interlinking compromised glymphatic function with aging in Parkinson's disease.

Xin Cai,Zhenzhen Chen,Chentao He,Piao Zhang,Kun Nie,Yihui Qiu,Limin Wang,Lijuan Wang,Ping Jing,Yuhu Zhang

CNS neuroscience & therapeutics（2023）

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摘要

The results demonstrate that reduced ALPS index, a potential noninvasive measure of compromised glymphatic activity, is involved in the pathophysiology of PD, especially in the aged ones and those with sleep disorders.

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关键词

Parkinson's disease,aging,diffusion tensor imaging,glymphatic system,sleep disorders

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