Testing for association between exonic glucagon-like peptide 1 receptor mutation with physical and brain health traits in UK Biobank

Joey Ward,Laura M. Lyall,Rona J. Strawbridge,Ioana Stanciu,Michele Veldsman,Victoria Garfield,Carlos Celis-Morales,Danielle Newby,William Stewart,Jill P. Pell,Naveed Sattar,Donald M. Lyall

Diabetes, obesity & metabolism（2023）

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摘要

These findings support clinical trial data in providing orthogonal, genetics-based evidence suggesting efficacy for GLP-1R agonists on physical health; but not necessarily directly for improved brain health including protection against dementia. Ongoing clinical trials are needed to provide more robust evidence. This article is protected by copyright. All rights reserved.

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关键词

GLP-1R,UK Biobank,cardiometabolic,dementia,imaging

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