Altered functional connectivity in psychotic disorder not otherwise specified

•Little research has examined clinical characteristics and brain imaging markers for psychotic disorder not otherwise specified (PNOS).•We found common brain connectomics in PNOS and schizophrenia (SZ) including thalamo– cortical hyperconnectivity, thalamo–cerebellar hypoconnectivity, and reduced within-thalamic connectivity compared to HC.•Distinct features differentiating two patient groups were hyperconnectivity between the thalamic subregion and anterior cingulate cortex in PNOS compared to SZ and hyperconnectivity of the thalamic subregions with the posterior cingulate cortex and precentral gyrus in SZ compared to PNOS.•Our results support the hypothesis that PNOS should be treated as a separate clinical syndrome with distinct neural connectomics.