Why does age at HIV infection correlate with set point viral load? An evolutionary hypothesis

Steven M Goodreau,Sarah E Stansfield,John E Mittler,James T Murphy,Neil F Abernethy,Geoffrey S Gottlieb,Molly C Reid, Juandalyn C Burke,Emily D Pollock,Joshua T Herbeck

Epidemics（2022）

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摘要

•Selection bottlenecks lead those with lower HIV risk to acquire more virulent virus.•Selection bottlenecks might explain why older persons average higher HIV viral load.•Selection bottlenecks include declining relational formation and coital acts by age.

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关键词

HIV-1,Set point viral load,Evolution,Age,Networks,Modeling

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