Effect of single housing on innate immune activation in SIV-infected pigtail macaques (Macaca nemestrina) as a model of psychosocial stress in acute HIV infection.

Natalie Castell,Selena M Guerrero-Martin,Leah H Rubin,Erin N Shirk,Jacqueline K Brockhurst,Claire E Lyons,Kevin M Najarro,Suzanne E Queen,Bess W Carlson,Robert J Adams,Craig N Morrell,Lucio Gama,David R Graham,Christine Zink,Joseph L Mankowski,Janice E Clements,Kelly A Metcalf Pate

Psychosomatic medicine（2022）

引用 3|浏览12

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摘要

Chronic psychosocial stress produced by single housing may play an immunomodulatory role in the innate immune response to acute retroviral infection. Dysregulated innate immunity could be one of the pathways by which psychosocial stress contributes to immune suppression and increased disease severity in PWH.

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