N2-Selective β-Thioalkylation of Benzotriazoles with Alkenes
The Journal of Organic Chemistry(2022)
摘要
Herein, N2-selective β-thioalkylation of benzotriazoles with unactivated alkenes and styrenes is reported. The N2-selective β-thioalkylation of benzotriazoles is highly stereospecific and works under simple and mild conditions, exhibiting excellent functional group tolerance. The high N2-selectivity is a consequence of the combination of hydrogen bonding and Lewis acid/base activation, which reverses the N2-position to be favored for alkylation.
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关键词
benzotriazoles
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