Analysis of BRCA2 Copy Number Loss and Genomic Instability in Circulating Tumor Cells from Patients with Metastatic Castration-resistant Prostate Cancer.

Ethan S Barnett,Nikolaus Schultz,Konrad H Stopsack,Ernest T Lam,Andrea Arfe,Jerry Lee,Jimmy L Zhao,Joseph D Schonhoft,Emily A Carbone,Niamh M Keegan,Andreas Wibmer,Yipeng Wang,David B Solit,Wassim Abida,Richard Wenstrup,Howard I Scher

European urology（2023）

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摘要

Current testing strategies have limitations in their ability to detect BRCA2 loss, a relatively common alteration in prostate cancer that is used to identify patients who may benefit from targeted therapy. In this paper, we evaluated whether we could detect BRCA2 loss in individual tumor cells isolated from patient blood samples and found this method to be suitable for further analysis.

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关键词

BRCA2,Circulating tumor cells,Copy number loss,Homologous recombination deficiency,Single-cell sequencing

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