MPN-225 Next Generation Sequencing (NGS) in the Diagnosis, Prognosis and Features of the Disease in Ph-Negative Myeloproliferative Neoplasms

Anna N. Kirienko,Ekaterina V. Motyko, Daria V. Kustova, Elizaveta V. Efremova,Elena V. Morozova,Dzhariyat I. Shikhbabaeva,Olga Yu Vinogradova,Natalya Yu Semenova,Natella I. Enukashvily, Vasilii A. Shuvaev, Sergey V. Voloshin,Sergey V. Sidorkevich,Irina S. Martynkevich

Clinical Lymphoma Myeloma and Leukemia（2022）

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摘要

NGS data can confirm disease clonal nature, assess disease prognosis, and select target therapy for patients with Ph-negative myeloproliferative neoplasms. To get new information it is possible to expand the panel of sequenced genes, as well as study other genetic mechanisms underlying disease pathogenesis (e.g., changes in gene expression level, microRNAs, or transcription factors).

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关键词

MPN,NGS,myeloproliferative neoplasms,Ph-negative

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