An Improved and Suitable Method for Large Scale Production of alpha-Monochlorocyclodecanone

alpha-Monochlorocyclododecanone was synthesized from cyclododecane and 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) catalyzed with silica gel in MeOH. The product was obtained by crystallization with a nearly 85% yield. The presented method used cheap raw materials, mild reaction conditions, a simple separation method, and an environment-friendly process. Additionally, the current synthesis provided an ideal approach for large-scale production.