SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis.

Eri Itotagawa,Yoshihiko Tomofuji,Yasuhiro Kato,Hachiro Konaka,Kohei Tsujimoto,JeongHoon Park,Daiki Nagira,Takehiro Hirayama,Tatsunori Jo,Toru Hirano,Takayoshi Morita,Masayuki Nishide,Sumiyuki Nishida,Yoshihito Shima,Masashi Narazaki, Yukinori Okada,Hyota Takamatsu,Atsushi Kumanogoh

Rheumatology (Oxford, England)（2022）

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摘要

Monitoring urinary BAFF-bioactivity may be valuable in diagnosing LN. Furthermore, stratification based on serum BAFF and IFN-I bioactivities may allow the identification of appropriate patients for biologics targeting BAFF and IFN-I.

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关键词

B-cell activating factor (BAFF),IFN-I,Lupus nephritis,Systemic lupus erythematosus,glomerular macrophages

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