Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers

Donghai Liang,Jonathan Batross,Nancy Fiedler,Tippawan Prapamontol,Panrapee Suttiwan,Parinya Panuwet,Warangkana Naksen,Brittney O. Baumert,Volha Yakimavets,Youran Tan,Priya D'Souza,Ampica Mangklabruks,Supattra Sittiwang,Kristsanachai Kaewthit,Kanyapak Kohsuwan,Nattawadee Promkam,Sureewan Pingwong,P. Barry Ryan,Dana Boyd Barr

Environmental Research（2022）

引用 4|浏览13

暂无评分

摘要

•Metabolomics identified biological pathways and metabolites perturbed by chlorpyrifos exposures among pregnant women in Thailand.•Perturbations in tryptophan, fatty acid, CYP450, glutathione, and vitamin B3 metabolisms associated with chlorpyrifos exposures.•25 metabolic features confirmed at level 1 confidence.•Pathways and metabolites mostly involved in inflammation, oxidative stress, neural development, and cellular damage and repair.

查看译文

关键词

Thailand,Farmworker,Birth cohort,Metabolomics,Organophosphate,Biomarkers

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要