Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood–brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1

Jian Huang,Jiuyang Ding, Xiaohan Wang,Cihang Gu, Yitong He,Yanning Li, Haoliang Fan,Qiqian Xie, Xiaolan Qi, Zhuo Wang,Pingming Qiu

Brain, Behavior, and Immunity（2022）

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摘要

•METH up-regulated the expression of α-syn in neurons and spread α-syn further into astrocytes.•The α-syn accumulated in astrocytes induced neuroinflammation and BBB damage by downregulating Nurr1 expression.•Knockout or inhibition of α-syn or astrocyte-specific overexpression of Nurr1 could partially alleviate symptoms associated with neuroinflammation and relieve BBB injury.

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关键词

blood–brain barrier damage,methamphetamine exposure,astrocytes,neuroinflammation,neuron-derived,receptor-associated

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