The effect of HIF-1α inhibition in breast cancer cells prior to doxorubicin treatment under conditions of normoxia and hypoxia

Carla Fourie,Manisha du Plessis, Justin Mills,Anna-Mart Engelbrecht

Experimental Cell Research（2022）

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摘要

•The over-expression of HIF-1 in malignant breast tissue serves as a negative prognostic indicator.•HIF-1 is considered a relevant target for therapeutic intervention.•Doxorubicin promotes autophagy under hypoxic conditions.•Upregulated HIF-1ɑ expression in a hypoxic environment promotes treatment resistance.

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关键词

Breast cancer,HIF-1α,Normoxia,Hypoxia,Apoptosis,Autophagy,Doxorubicin

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