Losartan, angiotensin ii type 1 receptor blocker, reduced aortic stiffness and improved cognitive function in dahl salt sensitive rat model of age-associated vascular dementia

Beneficial effect of LOS on cognitive function in aged male Dahl-S rats was associated with the improvement of cardiovascular function and remodeling. The CAS stabilizing and BP reduction by LOS treatment was associated with improved attentional performance, lower impulsivity and lower anxiety. The mechanistic basis of these effects of LOS on cognition via cerebrovascular and brain changes will be further investigated.