Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis.

Tobias Schatton,Yuta Itoh,Christina Martins,Erik Rasbach,Praveen Singh,Mariana Silva,Kyla Mucciarone,Markus V Heppt, Jenna Geddes-Sweeney, Kate Stewart, Anne Brandenburg,Jennifer Liang,Charles J Dimitroff,Martin C Mihm,Jennifer Landsberg,Christoph Schlapbach,Christine G Lian,George F Murphy,Thomas S Kupper,Matthew R Ramsey,Steven R Barthel

Cancer research（2022）

引用 6|浏览24

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摘要

Tim-3 is a growth-suppressive receptor intrinsic to melanoma cells, the blockade of which promotes MAPK-dependent tumorigenesis and thus counteracts antitumor activity of T-cell-directed Tim-3 inhibition.

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关键词

melanoma cell–intrinsic,mapk-dependent

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