Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia

•This study demonstrated that EVI-1 plays a key oncogenic role in AML by unbalancing the balance between NRAS and miR-124.•Our findings may open up a new avenue for our understanding of AML carcinogenesis and the development of new therapeutic options.