Menisperdaurines A-W, structurally diverse isoquinoline alkaloids from Menispermum dauricum and their dopamine D1 receptor activities

Hong-Li Wei,Yao-Peng Zhao,Ji-Xia Wang,Yang Han,Hao Li,Han Zhou,Tao Hou, Chang-Jian Wang,Yu-Min Yao,Xiu-Li Zhang,Yan-Fang Liu,Xin-Miao Liang

Bioorganic Chemistry（2022）

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摘要

A total of 33 structurally diverse isoquinoline alkaloids were isolated from the rhizomes of Menispermum dauricum, including 23 new and 10 known compounds. Compound 1 exhibited the highest D1 receptor antagonistic activity with an IC50 value of 1.0 ± 0.2 μM.

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关键词

Menispermum dauricum DC.,Menispermaceae,Isoquinoline alkaloids,Electronic circular dichroism,D1 antagonistic activity

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