IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice.

Jiyeon Ock,Jun-Kyu Suh,Soon-Sun Hong,Ju-Hee Kang,Guo Nan Yin,Ji-Kan Ryu

Andrology（2023）

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摘要

Knockdown of IGFBP5 improved erectile function in diabetic mice by promoting cell proliferation and reducing apoptosis and permeability. Local inhibition of IGFBP5 expression may provide a new treatment strategy for diabetic ED and other ischemic vascular or neurological diseases.

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关键词

angiopathy,diabetes,erectile dysfunction,insulin-like growth factor binding protein 5,permeability

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