ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.

Adam Kosti,Jennifer Chiou,Gabriela D A Guardia,Xiufen Lei, Henriette Balinda,Tesha Landry,Xiyuan Lu,Mei Qiao,Andrea Gilbert,Andrew Brenner,Pedro A F Galante,Stefano Tiziani,Luiz O F Penalva

Neuro-oncology（2023）

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摘要

We found that ELF4 is critical for the GBM cell identity by controlling genes of two dependent pathways: RTK signaling (SRC, PTK2B, and TNK2) and lipid dynamics (LRP1, APOE, ABCA7, PLA2G6, and PITPNM2). Our data suggest that targeting these two pathways simultaneously may be therapeutically beneficial to GBM patients.

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关键词

ELF4,RTK signaling,glioblastoma,lipid dynamics,miRNA-transcription factor networks

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