NIS mediated dehydrogenative-cyclocondensation in aqueous medium towards the synthesis of 2-arylimidazo[1,2-a]pyridines and their 3-formylated derivatives

An environmental friendly, NIS mediated oxidative cyclocondensation of 2-aminopyridine and aryl methyl ketone/cinnamaldehydes has been realized for the synthesis of 2-arylimidazo [1,2-a]pyridines and their 3-formylated products respectively. This one pot protocol involves simple reaction conditions, tolerates wide range of substrates and the products were formed in good to excellent yields.